| 4. Round | 27/02/2022 | Tacuary | - | Libertad | 0:1 | ||||
| 8. Round | 02/04/2022 | Guaireña FC | - | Libertad | 2:3 | ||||
| 12. Round | 23/04/2022 | Libertad | - | 12 de Octubre de Itauguá | 4:0 |  |
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| 13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 |  |
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| 18. Round | 14/06/2022 | Guaraní | - | Libertad | 1:1 | ||||
| 19. Round | 18/06/2022 | Libertad | - | Guaireña FC | 2:0 | ||||
| 20. Round | 21/06/2022 | Sol de América | - | Libertad | 0:3 | ||||
| 21. Round | 26/06/2022 | Libertad | - | Cerro Porteño | 1:0 |
Paraguay