| 2. Round | 25/07/2021 | Defensa y Justicia | - | Godoy Cruz | 1:2 | ||||
| 4. Round | 01/08/2021 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 |  |
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| 5. Round | 09/08/2021 | Aldosivi | - | Defensa y Justicia | 1:0 | ||||
| 6. Round | 17/08/2021 | Defensa y Justicia | - | Sarmiento de Junín | 4:2 | |
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| 7. Round | 21/08/2021 | Independiente | - | Defensa y Justicia | 0:0 | |
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| 8. Round | 25/08/2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
| 9. Round | 29/08/2021 | Arsenal de Sarandí | - | Defensa y Justicia | 0:0 | ||||
| 10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 | ||||
| 11. Round | 15/09/2021 | Boca Juniors | - | Defensa y Justicia | 0:0 | ||||
| 12. Round | 21/09/2021 | Defensa y Justicia | - | Banfield | 0:0 | ||||
| 13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
| 15. Round | 09/10/2021 | Argentinos Juniors | - | Defensa y Justicia | 0:2 | ||||
| 20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 |
Argentina