2. Round | 25/07/2021 | Defensa y Justicia | - | Godoy Cruz | 1:2 | ||||
4. Round | 01/08/2021 | Defensa y Justicia | - | Gimnasia de La Plata | 3:2 | ||||
5. Round | 09/08/2021 | Aldosivi | - | Defensa y Justicia | 1:0 | ||||
6. Round | 17/08/2021 | Defensa y Justicia | - | Sarmiento de Junín | 4:2 | ||||
7. Round | 21/08/2021 | Independiente | - | Defensa y Justicia | 0:0 | ||||
8. Round | 25/08/2021 | Defensa y Justicia | - | Newell's Old Boys | 2:0 | ||||
9. Round | 29/08/2021 | Arsenal de Sarandí | - | Defensa y Justicia | 0:0 | ||||
10. Round | 03/09/2021 | Defensa y Justicia | - | Central Córdoba SdE | 1:1 | ||||
11. Round | 15/09/2021 | Boca Juniors | - | Defensa y Justicia | 0:0 | ||||
12. Round | 21/09/2021 | Defensa y Justicia | - | Banfield | 0:0 | ||||
13. Round | 26/09/2021 | San Lorenzo | - | Defensa y Justicia | 2:1 | ||||
15. Round | 09/10/2021 | Argentinos Juniors | - | Defensa y Justicia | 0:2 | ||||
20. Round | 05/11/2021 | Defensa y Justicia | - | Rosario Central | 3:0 |