| 3. Round | 25/01/2025 | Club León | - | FC Juárez | 1:0 | ||||
| 4. Round | 29/01/2025 | Club León | - | Deportivo Guadalajara | 2:1 | ||||
| 5. Round | 01/02/2025 | Mazatlán FC | - | Club León | 1:2 | ||||
| 1. Round | 06/02/2025 | CF Pachuca | - | Club León | 1:2 |  |
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| 6. Round | 09/02/2025 | Club León | - | Deportivo Toluca | 3:3 |  |
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| 7. Round | 17/02/2025 | Atlético San Luis | - | Club León | 1:2 | ||||
| 9. Round | 20/02/2025 | CF América | - | Club León | 1:1 | |
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| 8. Round | 23/02/2025 | Club León | - | UANL Tigres | 1:0 | ||||
| 10. Round | 02/03/2025 | Club León | - | Club Tijuana | 2:1 | |
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| 11. Round | 09/03/2025 | Santos Laguna | - | Club León | 2:1 | |
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| 12. Round | 15/03/2025 | Club Necaxa | - | Club León | 2:1 | |
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| 14. Round | 05/04/2025 | Gallos Blancos | - | Club León | 1:1 | |
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| 15. Round | 13/04/2025 | Club León | - | Puebla FC | 1:0 | ||||
| 16. Round | 16/04/2025 | Cruz Azul | - | Club León | 2:1 | ||||
| 17. Round | 21/04/2025 | Club León | - | CF Monterrey | 0:2 |
Chile