| 1. Round | 13/09/2021 | Progreso | - | Villa Española | 1:1 |  |
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| 2. Round | 19/09/2021 | Nacional | - | Progreso | 0:1 | ||||
| 3. Round | 26/09/2021 | Progreso | - | Cerrito | 0:1 | |
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| 4. Round | 03/10/2021 | Liverpool | - | Progreso | 0:1 | ||||
| 5. Round | 09/10/2021 | Progreso | - | River Plate | 1:0 | ||||
| 6. Round | 17/10/2021 | Cerro Largo | - | Progreso | 1:0 | ||||
| 7. Round | 21/10/2021 | Progreso | - | Deportivo Maldonado | 2:0 | ||||
| 8. Round | 25/10/2021 | Progreso | - | Sud América | 0:0 | ||||
| 9. Round | 30/10/2021 | Plaza Colonia | - | Progreso | 2:1 | ||||
| 10. Round | 04/11/2021 | Progreso | - | Fénix | 1:0 | ||||
| 11. Round | 08/11/2021 | Boston River | - | Progreso | 0:0 | ||||
| 12. Round | 15/11/2021 | Progreso | - | Montevideo Wanderers | 3:1 | ||||
| 13. Round | 21/11/2021 | Rentistas | - | Progreso | 0:1 | ||||
| 14. Round | 25/11/2021 | Progreso | - | Peñarol | 0:0 | |
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| 15. Round | 04/12/2021 | Montevideo City Torque | - | Progreso | 1:0 |
Uruguay
Italy