| 1. Round | 05/09/2021 | UD Montijo | - | UD Las Palmas B | 0:1 | ||||
| 2. Round | 12/09/2021 | UD San Fernando | - | UD Montijo | 1:2 | ||||
| 3. Round | 19/09/2021 | UD Montijo | - | CF Panadería Pulido | 0:0 |  |
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| 5. Round | 03/10/2021 | UD Montijo | - | AD Ceuta FC | 1:0 | ||||
| 6. Round | 10/10/2021 | Antequera CF | - | UD Montijo | 2:1 | ||||
| 7. Round | 17/10/2021 | UD Montijo | - | Vélez CF | 1:0 | ||||
| 8. Round | 23/10/2021 | CD San Roque de Lepe | - | UD Montijo | 1:2 | |
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| 9. Round | 31/10/2021 | UD Montijo | - | Xerez DFC | 2:0 | ||||
| 10. Round | 06/11/2021 | Córdoba CF | - | UD Montijo | 3:1 | ||||
| 11. Round | 14/11/2021 | UD Montijo | - | Cádiz CF B | 1:1 | ||||
| 12. Round | 21/11/2021 | CP Cacereño | - | UD Montijo | 2:0 | ||||
| 13. Round | 27/11/2021 | UD Montijo | - | CD Coria | 1:0 | ||||
| 14. Round | 04/12/2021 | CF Villanovense | - | UD Montijo | 2:0 | ||||
| 4. Round | 08/12/2021 | CD Mensajero | - | UD Montijo | 1:0 | ||||
| 15. Round | 12/12/2021 | UD Montijo | - | Don Benito | 3:1 | ||||
| 16. Round | 19/12/2021 | UD Montijo | - | Mérida AD | 2:0 |  |
Chile