1. Round | 09/01/2021 | Mazatlán FC | - | Club Necaxa | 3:2 | ||||
2. Round | 17/01/2021 | Pumas UNAM | - | Mazatlán FC | 3:0 | ||||
3. Round | 23/01/2021 | Mazatlán FC | - | Santos Laguna | 0:0 | ||||
13. Round | 03/04/2021 | Puebla FC | - | Mazatlán FC | 3:1 | ||||
14. Round | 12/04/2021 | Club Tijuana | - | Mazatlán FC | 2:3 | ||||
15. Round | 17/04/2021 | Mazatlán FC | - | Atlas Guadalajara | 0:0 | ||||
16. Round | 24/04/2021 | Mazatlán FC | - | Club León | 4:3 | ||||
17. Round | 02/05/2021 | CF Monterrey | - | Mazatlán FC | 1:0 |