| 2. Round | 16/01/2021 | Deportivo Guadalajara [U20] | - | Deportivo Toluca [U20] | 5:3 | ||||
| 3. Round | 21/01/2021 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 3:2 |  |
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| 4. Round | 30/01/2021 | Deportivo Guadalajara [U20] | - | FC Juárez [U20] | 0:1 | ||||
| 5. Round | 08/02/2021 | Club León [U20] | - | Deportivo Guadalajara [U20] | 3:0 | ||||
| 6. Round | 13/02/2021 | Deportivo Guadalajara [U20] | - | Club Necaxa [U20] | 1:0 | ||||
| 7. Round | 22/02/2021 | CF Pachuca [U20] | - | Deportivo Guadalajara [U20] | 3:2 |  |
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| 8. Round | 28/02/2021 | Deportivo Guadalajara [U20] | - | Pumas UNAM [U20] | 1:2 | |
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| 1. Round | 27/03/2021 | Puebla FC [U20] | - | Deportivo Guadalajara [U20] | 2:4 | ||||
| 14. Round | 10/04/2021 | Cruz Azul [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 17. Round | 01/05/2021 | Deportivo Guadalajara [U20] | - | UANL Tigres [U20] | 1:1 |
Mexico