| Group 1 | 16/02/2011 | Club San Luis | - | Libertad | 1:2 |  |
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| Group 1 | 23/02/2011 | Once Caldas | - | Libertad | 1:1 | ||||
| Group 1 | 08/03/2011 | Libertad | - | Universidad San Martín | 5:1 |  |
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| Group 1 | 15/03/2011 | Universidad San Martín | - | Libertad | 0:1 | ||||
| Group 1 | 23/03/2011 | Libertad | - | Once Caldas | 2:2 | ||||
| Group 1 | 20/04/2011 | Libertad | - | Club San Luis | 2:0 | ||||
| Round of 16 | 29/04/2011 | Fluminense RJ | - | Libertad | 3:1 | ||||
| Round of 16 | 05/05/2011 | Libertad | - | Fluminense RJ | 3:0 | |
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| Quarter-finals | 13/05/2011 | Vélez Sarsfield | - | Libertad | 3:0 | ||||
| Quarter-finals | 18/05/2011 | Libertad | - | Vélez Sarsfield | 2:4 | |
Paraguay