| 1. Round | 17/10/2020 | Club Olimpia | - | Club Nacional | 1:1 | ||||
| 2. Round | 25/10/2020 | Guaireña FC | - | Club Olimpia | 2:1 | ||||
| 3. Round | 01/11/2020 | Club Olimpia | - | San Lorenzo | 3:1 | ||||
| 4. Round | 09/11/2020 | Sol de América | - | Club Olimpia | 1:3 |  |
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| 7. Round | 22/11/2020 | Sportivo Luqueño | - | Club Olimpia | 2:2 | ||||
| 8. Round | 28/11/2020 | Club Olimpia | - | River Plate | 3:1 | ||||
| 6. Round | 03/12/2020 | Cerro Porteño | - | Club Olimpia | 1:0 |  |
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| 9. Round | 06/12/2020 | Guaraní | - | Club Olimpia | 2:0 | ||||
| 10. Round | 12/12/2020 | Club Olimpia | - | General Díaz | 4:2 | ||||
| 11. Round | 19/12/2020 | Libertad | - | Club Olimpia | 2:1 |
Paraguay