| 1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 |  |
|||
| 2. Round | 10/02/2021 | 12 de Octubre de Itauguá | - | Club Olimpia | 0:2 | ||||
| 3. Round | 14/02/2021 | Club Olimpia | - | Guaireña FC | 0:0 | ||||
| 4. Round | 20/02/2021 | Guaraní | - | Club Olimpia | 0:3 | ||||
| 8. Round | 14/03/2021 | Sportivo Luqueño | - | Club Olimpia | 4:2 | ||||
| 9. Round | 21/03/2021 | Club Olimpia | - | River Plate | 5:1 |  |
|||
| 10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 11. Round | 11/04/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 2:2 | ||||
| 12. Round | 16/04/2021 | Guaireña FC | - | Club Olimpia | 1:2 | ||||
| 13. Round | 25/04/2021 | Club Olimpia | - | Guaraní | 2:1 | ||||
| 14. Round | 02/05/2021 | Cerro Porteño | - | Club Olimpia | 2:0 | |
|||
| 16. Round | 17/05/2021 | Club Nacional | - | Club Olimpia | 2:1 | ||||
| 17. Round | 23/05/2021 | Club Olimpia | - | Sportivo Luqueño | 4:1 | ||||
| 18. Round | 30/05/2021 | River Plate | - | Club Olimpia | 1:2 |
Paraguay