| 2. Round | 07/08/2022 | Defensor Sporting | - | Peñarol | 2:3 | ||||
| 3. Round | 13/08/2022 | Peñarol | - | Albion | 2:0 | ||||
| 7. Round | 11/09/2022 | Peñarol | - | Rentistas | 2:2 | ||||
| 8. Round | 15/09/2022 | Liverpool | - | Peñarol | 0:1 | ||||
| 9. Round | 18/09/2022 | Peñarol | - | Cerrito | 3:1 | ||||
| 10. Round | 24/09/2022 | Peñarol | - | Montevideo City Torque | 0:1 | ||||
| 11. Round | 02/10/2022 | Montevideo Wanderers | - | Peñarol | 0:2 | ||||
| 12. Round | 09/10/2022 | Peñarol | - | Plaza Colonia | 0:1 |  |
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| 14. Round | 16/10/2022 | Peñarol | - | River Plate | 1:1 | |
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| 15. Round | 22/10/2022 | Cerro Largo | - | Peñarol | 0:2 |  |
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Uruguay