| 3. Round | 16/06/2021 | Villa Teresa | - | Rampla Juniors | 0:1 | ||||
| 4. Round | 25/06/2021 | Rampla Juniors | - | Juventud de Las Piedras | 0:2 | ||||
| 5. Round | 02/07/2021 | Uruguay Montevideo | - | Rampla Juniors | 2:0 | ||||
| 9. Round | 31/07/2021 | Rampla Juniors | - | CA Cerro | 0:1 | ||||
| 10. Round | 05/08/2021 | Defensor Sporting | - | Rampla Juniors | 1:0 | ||||
| 11. Round | 12/08/2021 | Rampla Juniors | - | Central Español | 2:1 | ||||
| 12. Round | 15/09/2021 | Rampla Juniors | - | Atenas | 2:1 | ||||
| 13. Round | 22/09/2021 | Racing | - | Rampla Juniors | 2:0 | ||||
| 16. Round | 12/10/2021 | Rampla Juniors | - | Uruguay Montevideo | 1:1 | ||||
| 17. Round | 19/10/2021 | Albion | - | Rampla Juniors | 2:0 | ||||
| 18. Round | 27/10/2021 | Danubio | - | Rampla Juniors | 2:0 |  |
|||
| 21. Round | 18/11/2021 | Rampla Juniors | - | Defensor Sporting | 0:5 | ||||
| 22. Round | 25/11/2021 | Central Español | - | Rampla Juniors | 3:0 |
Uruguay