| 8. Round | 12/06/2022 | Miramar Misiones | - | Villa Española | 1:0 | ||||
| 12. Round | 24/07/2022 | Rampla Juniors | - | Villa Española | 1:0 | ||||
| 13. Round | 30/07/2022 | Villa Española | - | Progreso | 0:0 | ||||
| 14. Round | 07/08/2022 | La Luz | - | Villa Española | 1:1 |  |
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| 15. Round | 13/08/2022 | Villa Española | - | Atenas | 0:0 | ||||
| 16. Round | 19/08/2022 | CA Cerro | - | Villa Española | 1:1 | |
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| 17. Round | 24/08/2022 | Villa Española | - | Sud América | 1:0 | ||||
| 18. Round | 28/08/2022 | Central Español | - | Villa Española | 2:0 | ||||
| 19. Round | 03/09/2022 | Villa Española | - | Miramar Misiones | 1:2 |
Uruguay