| 1. Round | 17/01/2021 | Progreso | - | Montevideo City Torque | 0:0 | ||||
| 2. Round | 21/01/2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 3. Round | 30/01/2021 | Progreso | - | Liverpool | 0:4 | ||||
| 4. Round | 02/02/2021 | Progreso | - | Fénix | 0:1 | ||||
| 5. Round | 07/02/2021 | CA Cerro | - | Progreso | 2:0 | ||||
| 6. Round | 11/02/2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 7. Round | 15/02/2021 | Danubio | - | Progreso | 0:1 |  |
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| 8. Round | 18/02/2021 | Progreso | - | Nacional | 0:1 | |
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| 9. Round | 23/02/2021 | Boston River | - | Progreso | 2:3 | ||||
| 13. Round | 21/03/2021 | Montevideo Wanderers | - | Progreso | 3:0 dec. |  |
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| 14. Round | 25/03/2021 | Progreso | - | Peñarol | 0:2 | ||||
| 15. Round | 29/03/2021 | River Plate | - | Progreso | 3:2 | |
Uruguay