| 1. Round | 13/09/2021 | Liverpool | - | Deportivo Maldonado | 1:0 | ||||
| 2. Round | 19/09/2021 | Liverpool | - | River Plate | 3:1 | ||||
| 3. Round | 25/09/2021 | Cerro Largo | - | Liverpool | 3:0 | ||||
| 4. Round | 03/10/2021 | Liverpool | - | Progreso | 0:1 | ||||
| 6. Round | 16/10/2021 | Liverpool | - | Plaza Colonia | 0:1 |  |
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| 10. Round | 03/11/2021 | Liverpool | - | Rentistas | 0:1 | |
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| 11. Round | 07/11/2021 | Peñarol | - | Liverpool | 1:0 | ||||
| 12. Round | 13/11/2021 | Liverpool | - | Montevideo City Torque | 1:3 | ||||
| 13. Round | 19/11/2021 | Villa Española | - | Liverpool | 0:3 | ||||
| 14. Round | 26/11/2021 | Liverpool | - | Nacional | 2:2 | |
Uruguay