| 3. Round | 19/02/2022 | River Plate | - | Boston River | 1:2 |  |
|||
| 4. Round | 25/02/2022 | Boston River | - | Cerro Largo | 3:0 |  |
|||
| 5. Round | 12/03/2022 | Fénix | - | Boston River | 0:2 | ||||
| 6. Round | 21/03/2022 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 7. Round | 02/04/2022 | Albion | - | Boston River | 1:2 | |
|||
| 8. Round | 10/04/2022 | Boston River | - | Nacional | 0:6 | ||||
| 10. Round | 24/04/2022 | Boston River | - | Deportivo Maldonado | 2:0 | ||||
| 11. Round | 08/05/2022 | Rentistas | - | Boston River | 0:1 | ||||
| 12. Round | 16/05/2022 | Boston River | - | Liverpool | 2:3 | ||||
| 13. Round | 21/05/2022 | Peñarol | - | Boston River | 1:0 | ||||
| 15. Round | 06/06/2022 | Montevideo Wanderers | - | Boston River | 1:2 |
Uruguay