| 1. Round | 30/07/2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Round | 06/08/2022 | Cerrito | - | Boston River | 0:3 | ||||
| 3. Round | 12/08/2022 | Boston River | - | River Plate | 1:2 |  |
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| 6. Round | 21/08/2022 | Defensor Sporting | - | Boston River | 0:1 | ||||
| 5. Round | 26/08/2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Round | 04/09/2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 7. Round | 10/09/2022 | Boston River | - | Albion | 1:0 | |
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| 9. Round | 19/09/2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Round | 23/09/2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Round | 02/10/2022 | Boston River | - | Rentistas | 3:0 | ||||
| 12. Round | 09/10/2022 | Liverpool | - | Boston River | 3:2 | ||||
| 14. Round | 17/10/2022 | Montevideo City Torque | - | Boston River | 0:2 | ||||
| 15. Round | 24/10/2022 | Boston River | - | Montevideo Wanderers | 2:2 | |
Uruguay