| 1. Round | 08/08/2010 | River Plate | - | Tigre | 1:0 |  |
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| 2. Round | 15/08/2010 | Huracán | - | River Plate | 0:1 | ||||
| 3. Round | 22/08/2010 | River Plate | - | Independiente | 3:2 | |
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| 4. Round | 29/08/2010 | Argentinos Juniors | - | River Plate | 0:0 | ||||
| 5. Round | 06/09/2010 | Vélez Sarsfield | - | River Plate | 2:1 | ||||
| 6. Round | 12/09/2010 | River Plate | - | Arsenal de Sarandí | 1:0 | |
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| 7. Round | 19/09/2010 | Newell's Old Boys | - | River Plate | 1:0 | ||||
| 8. Round | 27/09/2010 | River Plate | - | Quilmes | 1:1 | ||||
| 9. Round | 04/10/2010 | Banfield | - | River Plate | 2:2 | |
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| 10. Round | 11/10/2010 | River Plate | - | Gimnasia de La Plata | 0:0 | ||||
| 11. Round | 18/10/2010 | Godoy Cruz | - | River Plate | 2:2 | |
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| 12. Round | 23/10/2010 | River Plate | - | Racing Club | 1:1 | ||||
| 13. Round | 07/11/2010 | All Boys | - | River Plate | 1:0 | ||||
| 14. Round | 16/11/2010 | River Plate | - | Boca Juniors | 1:0 | ||||
| 15. Round | 21/11/2010 | San Lorenzo | - | River Plate | 0:0 | ||||
| 16. Round | 28/11/2010 | River Plate | - | Olimpo de Bahía Blanca | 1:0 | ||||
| 17. Round | 04/12/2010 | Colón de Santa Fe | - | River Plate | 1:2 | ||||
| 18. Round | 08/12/2010 | River Plate | - | Estudiantes | 0:4 | |
Argentina
USA 