| 3. Round | 07/08/2021 | Mazatlán FC | - | CF Monterrey | 1:1 | ||||
| 4. Round | 15/08/2021 | CF Monterrey | - | CF Pachuca | 3:1 |  |
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| 5. Round | 19/08/2021 | Cruz Azul | - | CF Monterrey | 1:1 | ||||
| 6. Round | 22/08/2021 | CF Monterrey | - | Deportivo Guadalajara | 0:0 | ||||
| 7. Round | 28/08/2021 | Club Tijuana | - | CF Monterrey | 2:2 | |
 |
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| 9. Round | 20/09/2021 | CF Monterrey | - | UANL Tigres | 2:0 | ||||
| 11. Round | 23/09/2021 | CF Monterrey | - | Deportivo Toluca | 2:0 | |
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| 10. Round | 27/09/2021 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
| 12. Round | 02/10/2021 | FC Juárez | - | CF Monterrey | 3:1 | |
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| 13. Round | 16/10/2021 | CF Monterrey | - | Club León | 0:1 | |
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| 14. Round | 19/10/2021 | Gallos Blancos | - | CF Monterrey | 1:0 | ||||
| 15. Round | 23/10/2021 | CF Monterrey | - | Club Necaxa | 0:1 | ||||
| 16. Round | 01/11/2021 | Atlético San Luis | - | CF Monterrey | 1:1 | ||||
| 17. Round | 07/11/2021 | CF América | - | CF Monterrey | 0:0 |
Argentina
USA 