| 1. Round | 12/01/2025 | Pumas UNAM | - | Club Necaxa | 2:1 | ||||
| 2. Round | 19/01/2025 | Gallos Blancos | - | Pumas UNAM | 3:2 | ||||
| 3. Round | 26/01/2025 | Pumas UNAM | - | Atlas Guadalajara | 0:0 | ||||
| 5. Round | 03/02/2025 | Atlético San Luis | - | Pumas UNAM | 2:3 | ||||
| 8. Round | 23/02/2025 | Pumas UNAM | - | CF América | 0:2 | ||||
| 9. Round | 26/02/2025 | Club Tijuana | - | Pumas UNAM | 4:2 |  |
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| 10. Round | 02/03/2025 | Pumas UNAM | - | Deportivo Guadalajara | 0:1 | ||||
| 11. Round | 08/03/2025 | Puebla FC | - | Pumas UNAM | 1:3 | ||||
| 12. Round | 17/03/2025 | Pumas UNAM | - | CF Monterrey | 1:3 | ||||
| 13. Round | 31/03/2025 | Club León | - | Pumas UNAM | 1:2 | ||||
| 14. Round | 06/04/2025 | Cruz Azul | - | Pumas UNAM | 3:2 | |
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| 15. Round | 13/04/2025 | Pumas UNAM | - | FC Juárez | 0:0 | ||||
| 16. Round | 17/04/2025 | Pumas UNAM | - | Santos Laguna | 2:0 | ||||
| 17. Round | 20/04/2025 | UANL Tigres | - | Pumas UNAM | 2:1 | |
Argentina
USA 