| 7. Round | 31/03/2021 | Guayaquil City | - | Orense SC | 4:1 |  |
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| 6. Round | 04/04/2021 | Técnico Universitario | - | Guayaquil City | 3:0 | |
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| 8. Round | 13/04/2021 | 9 de Octubre | - | Guayaquil City | 4:0 | ||||
| 12. Round | 16/05/2021 | Emelec | - | Guayaquil City | 1:0 | ||||
| 14. Round | 29/05/2021 | Guayaquil City | - | Mushuc Runa | 0:0 | ||||
| 15. Round | 17/07/2021 | Aucas | - | Guayaquil City | 3:0 |
Ecuador