| 1. Round | 26/03/2010 | Seattle Sounders | - | Philadelphia Union | 2:0 | ||||
| 2. Round | 04/04/2010 | Seattle Sounders | - | New York RB | 0:1 | ||||
| 2. Round | 11/04/2010 | Real Salt Lake | - | Seattle Sounders | 2:2 | ||||
| 2. Round | 23/04/2010 | FC Dallas | - | Seattle Sounders | 2:2 | ||||
| 3. Round | 30/05/2010 | Colorado Rapids | - | Seattle Sounders | 1:0 | ||||
| 4. Round | 06/06/2010 | Seattle Sounders | - | New England Revolution | 3:0 | ||||
| 4. Round | 11/06/2010 | Seattle Sounders | - | D.C. United | 2:3 | ||||
| 4. Round | 27/06/2010 | Philadelphia Union | - | Seattle Sounders | 3:1 | ||||
| 5. Round | 12/07/2010 | Seattle Sounders | - | FC Dallas | 1:1 | ||||
| 5. Round | 16/07/2010 | D.C. United | - | Seattle Sounders | 0:1 |  |
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| 5. Round | 26/07/2010 | Seattle Sounders | - | Colorado Rapids | 2:1 | ||||
| 6. Round | 15/08/2010 | CD Chivas | - | Seattle Sounders | 0:0 | ||||
| 6. Round | 29/08/2010 | Seattle Sounders | - | Chicago Fire | 2:1 | ||||
| 7. Round | 05/09/2010 | New England Revolution | - | Seattle Sounders | 3:1 | ||||
| 7. Round | 19/09/2010 | Columbus Crew | - | Seattle Sounders | 0:4 | ||||
| 7. Round | 26/09/2010 | Chicago Fire | - | Seattle Sounders | 0:1 |
USA