| 1. Round | 05/03/2022 | Spartak Trnava | - | ŠKF Sereď | 0:1 |  |
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| 2. Round | 12/03/2022 | ŠKF Sereď | - | MŠK Žilina | 1:1 | ||||
| 3. Round | 19/03/2022 | Slovan Bratislava | - | ŠKF Sereď | 5:1 | ||||
| 4. Round | 02/04/2022 | FC DAC 1904 | - | ŠKF Sereď | 0:0 | |
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| 5. Round | 10/04/2022 | ŠKF Sereď | - | MFK Ružomberok | 1:3 | ||||
| 6. Round | 17/04/2022 | ŠKF Sereď | - | Spartak Trnava | 0:2 | ||||
| 7. Round | 23/04/2022 | MŠK Žilina | - | ŠKF Sereď | 1:1 | ||||
| 9. Round | 14/05/2022 | ŠKF Sereď | - | Slovan Bratislava | 0:3 | |
Croatia