| 1. Round | 25/07/2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 2. Round | 01/08/2021 | Vorskla Poltava | - | Rukh Lviv | 2:0 |  |
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| 3. Round | 07/08/2021 | Rukh Lviv | - | NK Veres | 2:1 | ||||
| 4. Round | 15/08/2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | |
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| 5. Round | 21/08/2021 | SK Dnipro-1 | - | Rukh Lviv | 2:0 | ||||
| 15. Round | 20/11/2021 | Shakhtar Donetsk | - | Rukh Lviv | 2:0 | |
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| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Rukh Lviv | - | Vorskla Poltava | 0:0 | ||||
| 18. Round | 11/12/2021 | NK Veres | - | Rukh Lviv | 1:1 |
Ukraine