| 1. Round | 25/07/2021 | Metalist 1925 Kharkiv | - | Rukh Lviv | 2:1 | ||||
| 3. Round | 07/08/2021 | Rukh Lviv | - | NK Veres | 2:1 | ||||
| 4. Round | 15/08/2021 | Kolos Kovalivka | - | Rukh Lviv | 1:1 | ||||
| 6. Round | 29/08/2021 | Rukh Lviv | - | FK Lviv | 1:0 | ||||
| 7. Round | 11/09/2021 | Rukh Lviv | - | Zorya Lugansk | 1:1 | ||||
| 8. Round | 17/09/2021 | Desna Chernigov | - | Rukh Lviv | 1:0 | ||||
| 9. Round | 25/09/2021 | Rukh Lviv | - | Dinamo Kiev | 0:2 |  |
Ukraine