| 2. Round | 24/07/2021 | FK Chelyabinsk | - | FK Orenburg 2 | 2:0 | ||||
| 3. Round | 04/08/2021 | FK Orenburg 2 | - | Dinamo Barnaul | 1:2 | ||||
| 4. Round | 07/08/2021 | FK Orenburg 2 | - | Irtysh Omsk | 1:1 | ||||
| 15. Round | 17/10/2021 | FK Orenburg 2 | - | Zenit Izhevsk | 2:2 | ||||
| 16. Round | 23/10/2021 | Zenit Izhevsk | - | FK Orenburg 2 | 1:1 | ||||
| 17. Round | 31/10/2021 | FK Orenburg 2 | - | Nosta Novotroitsk | 0:2 | ||||
| 18. Round | 04/11/2021 | FK Amkar Perm | - | FK Orenburg 2 | 3:0 | ||||
| 19. Round | 09/11/2021 | FK Novosibirsk | - | FK Orenburg 2 | 1:0 | ||||
| 23. Round | 17/04/2022 | FK Tyumen | - | FK Orenburg 2 | 4:0 |  |
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| 24. Round | 24/04/2022 | Spartak Tuymazy | - | FK Orenburg 2 | 1:2 | ||||
| 25. Round | 30/04/2022 | FK Orenburg 2 | - | Volga Ulyanovsk | 2:3 | ||||
| 26. Round | 08/05/2022 | FK Orenburg 2 | - | FK Ural 2 | 2:2 | ||||
| 27. Round | 18/05/2022 | Irtysh Omsk | - | FK Orenburg 2 | 1:1 | ||||
| 28. Round | 21/05/2022 | Dinamo Barnaul | - | FK Orenburg 2 | 3:0 | ||||
| 29. Round | 28/05/2022 | FK Orenburg 2 | - | FK Chelyabinsk | 0:3 | ||||
| 30. Round | 04/06/2022 | Torpedo Miass | - | FK Orenburg 2 | 2:1 | |
Russia