| 1. Round | 19/09/2020 | Leones Negros II | - | Tecos Fútbol Club | 2:1 |  |
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| 2. Round | 26/09/2020 | Mineros de Fresnillo FC | - | Leones Negros II | 5:1 | ||||
| 3. Round | 04/10/2020 | Leones Negros II | - | Mazorqueros | 1:2 | ||||
| 4. Round | 10/10/2020 | Atlético San Luis II | - | Leones Negros II | 0:2 | |
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| 5. Round | 17/10/2020 | Leones Negros II | - | Reboceros de La Piedad | 0:1 | ||||
| 6. Round | 23/10/2020 | Gavilanes de Matamoros | - | Leones Negros II | 1:0 | ||||
| 12. Round | 16/01/2021 | Tecos Fútbol Club | - | Leones Negros II | 2:3 | |
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| 13. Round | 23/01/2021 | Leones Negros II | - | Mineros de Fresnillo FC | 2:2 |  |
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| 15. Round | 07/02/2021 | Leones Negros II | - | Atlético San Luis II | 1:2 |
Mexico