| 10. Round | 29/10/2008 | SC Freiburg | - | 1. FSV Mainz 05 | 0:1 | ||||
| 11. Round | 02/11/2008 | Rot Weiss Ahlen | - | 1. FSV Mainz 05 | 0:2 | ||||
| 13. Round | 16/11/2008 | TuS Koblenz | - | 1. FSV Mainz 05 | 0:3 | ||||
| 14. Round | 23/11/2008 | 1. FSV Mainz 05 | - | FC St. Pauli | 2:2 | ||||
| 16. Round | 05/12/2008 | 1. FSV Mainz 05 | - | SpVgg Greuther Fürth | 0:1 | ||||
| 17. Round | 14/12/2008 | Rot-Weiß Oberhausen | - | 1. FSV Mainz 05 | 2:1 | ||||
| 20. Round | 15/02/2009 | VfL Osnabrück | - | 1. FSV Mainz 05 | 1:3 | ||||
| 21. Round | 20/02/2009 | 1. FSV Mainz 05 | - | Hansa Rostock | 3:1 | ||||
| 22. Round | 27/02/2009 | 1. FC Nürnberg | - | 1. FSV Mainz 05 | 0:0 |  |
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| 23. Round | 08/03/2009 | 1. FSV Mainz 05 | - | FC Augsburg | 1:1 | ||||
| 26. Round | 03/04/2009 | MSV Duisburg | - | 1. FSV Mainz 05 | 0:1 | ||||
| 28. Round | 17/04/2009 | 1. FSV Mainz 05 | - | Rot Weiss Ahlen | 0:0 | ||||
| 30. Round | 03/05/2009 | 1. FSV Mainz 05 | - | TuS Koblenz | 2:0 | ||||
| 31. Round | 10/05/2009 | FC St. Pauli | - | 1. FSV Mainz 05 | 2:0 | ||||
| 32. Round | 13/05/2009 | 1. FSV Mainz 05 | - | FSV Frankfurt | 2:1 | ||||
| 33. Round | 17/05/2009 | SpVgg Greuther Fürth | - | 1. FSV Mainz 05 | 0:2 | |
Ukraine
Germany 
