| 13. Round | 28/11/2021 | Swift Hesperange | - | F91 Dudelange | 1:0 | ||||
| 14. Round | 05/12/2021 | Jeunesse Esch | - | Swift Hesperange | 1:0 | ||||
| 17. Round | 13/02/2022 | Swift Hesperange | - | US Mondorf | 2:1 |  |
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| 16. Round | 16/02/2022 | Union Titus Pétange | - | Swift Hesperange | 0:3 | ||||
| 18. Round | 20/02/2022 | Etzella Ettelbruck | - | Swift Hesperange | 0:2 | ||||
| 19. Round | 27/02/2022 | Swift Hesperange | - | FC Differdange 03 | 3:0 | ||||
| 20. Round | 06/03/2022 | Victoria Rosport | - | Swift Hesperange | 0:4 | ||||
| 21. Round | 13/03/2022 | Swift Hesperange | - | CS FOLA Esch | 1:1 | ||||
| 22. Round | 20/03/2022 | UNA Strassen | - | Swift Hesperange | 0:2 | ||||
| 23. Round | 02/04/2022 | Progrès Niedercorn | - | Swift Hesperange | 2:2 | ||||
| 27. Round | 01/05/2022 | F91 Dudelange | - | Swift Hesperange | 1:0 | ||||
| 28. Round | 08/05/2022 | Swift Hesperange | - | Jeunesse Esch | 1:1 | ||||
| 29. Round | 15/05/2022 | US Hostert | - | Swift Hesperange | 1:3 | ||||
| 30. Round | 22/05/2022 | Swift Hesperange | - | RFCU Luxemburg | 2:0 |
France