| 2. Round | 23/07/2021 | Argentinos Juniors II | - | Newell's Old Boys II | 3:1 | ||||
| 5. Round | 06/08/2021 | Boca Juniors II | - | Argentinos Juniors II | 0:1 | ||||
| 7. Round | 20/08/2021 | San Lorenzo II | - | Argentinos Juniors II | 1:3 | ||||
| 10. Round | 03/09/2021 | Estudiantes II | - | Argentinos Juniors II | 2:0 | ||||
| 11. Round | 10/09/2021 | Argentinos Juniors II | - | Patronato de Paraná II | 3:0 | ||||
| 12. Round | 16/09/2021 | Platense II | - | Argentinos Juniors II | 2:2 | ||||
| 13. Round | 27/09/2021 | Argentinos Juniors II | - | Racing Club II | 2:1 | ||||
| 14. Round | 01/10/2021 | Rosario Central II | - | Argentinos Juniors II | 0:2 | ||||
| 16. Round | 17/10/2021 | Atlético Tucumán II | - | Argentinos Juniors II | 0:0 | ||||
| 20. Round | 09/11/2021 | Huracán II | - | Argentinos Juniors II | 1:0 | ||||
| 21. Round | 18/11/2021 | Argentinos Juniors II | - | Godoy Cruz II | 1:1 | ||||
| 25. Round | 11/12/2021 | Argentinos Juniors II | - | Sarmiento de Junín II | 1:2 |
Argentina