| 1. Round | 11/07/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:2 | ||||
| 2. Round | 18/07/2022 | Club León [Women] | - | Atlas Guadalajara [Women] | 1:1 | ||||
| 4. Round | 28/07/2022 | CF Pachuca [Women] | - | Club León [Women] | 3:0 | ||||
| 5. Round | 02/08/2022 | Santos Laguna [Women] | - | Club León [Women] | 1:2 | ||||
| 6. Round | 09/08/2022 | Club León [Women] | - | CF América [Women] | 2:2 | ||||
| 7. Round | 12/08/2022 | CF Monterrey [Women] | - | Club León [Women] | 3:0 | ||||
| 8. Round | 23/08/2022 | Club León [Women] | - | Atlético San Luis [Women] | 0:1 | ||||
| 11. Round | 12/09/2022 | Club León [Women] | - | Gallos Blancos [Women] | 0:1 | ||||
| 14. Round | 26/09/2022 | Club León [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 15. Round | 01/10/2022 | Pumas UNAM [Women] | - | Club León [Women] | 4:0 |
Mexico