| 6. Round | 10/09/2021 | Telstar | - | Almere City FC | 1:1 | ||||
| 7. Round | 17/09/2021 | FC Dordrecht | - | Telstar | 0:1 | ||||
| 8. Round | 24/09/2021 | Telstar | - | AZ Alkmaar (J) | 1:0 |  |
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| 9. Round | 01/10/2021 | FC Den Bosch | - | Telstar | 0:1 | ||||
| 21. Round | 09/01/2022 | FC Volendam | - | Telstar | 2:1 | ||||
| 22. Round | 14/01/2022 | Telstar | - | MVV | 2:1 | ||||
| 23. Round | 23/01/2022 | Telstar | - | Jong Ajax | 1:0 | ||||
| 24. Round | 30/01/2022 | Almere City FC | - | Telstar | 0:0 | ||||
| 29. Round | 04/03/2022 | Telstar | - | TOP Oss | 2:2 | ||||
| 30. Round | 07/03/2022 | AZ Alkmaar (J) | - | Telstar | 3:2 | ||||
| 27. Round | 14/03/2022 | Telstar | - | NAC Breda | 1:4 | ||||
| 31. Round | 18/03/2022 | Telstar | - | FC Dordrecht | 1:0 | ||||
| 28. Round | 21/03/2022 | ADO Den Haag | - | Telstar | 2:1 | ||||
| 32. Round | 27/03/2022 | FC Emmen | - | Telstar | 2:1 | ||||
| 33. Round | 01/04/2022 | Telstar | - | FC Den Bosch | 1:2 | ||||
| 34. Round | 08/04/2022 | SBV Excelsior | - | Telstar | 1:4 |
Spain