| 3. Round | 16/02/2018 | Deportivo Santaní | - | Libertad | 1:2 |  |
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| 4. Round | 23/02/2018 | Libertad | - | Cerro Porteño | 1:1 | ||||
| 11. Round | 08/04/2018 | Libertad | - | General Díaz | 1:0 | ||||
| 9. Round | 12/04/2018 | Libertad | - | Club Olimpia | 0:1 | ||||
| 13. Round | 22/04/2018 | Guaraní | - | Libertad | 0:2 | ||||
| 14. Round | 30/04/2018 | Libertad | - | Deportivo Santaní | 1:1 | ||||
| 15. Round | 07/05/2018 | Cerro Porteño | - | Libertad | 0:2 | |
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| 18. Round | 22/05/2018 | Libertad | - | Club Nacional | 0:0 |
Paraguay