1. Round | 24/07/2021 | Club Necaxa | - | Santos Laguna | 0:3 | ||||
2. Round | 02/08/2021 | Santos Laguna | - | Cruz Azul | 1:1 | ||||
3. Round | 08/08/2021 | UANL Tigres | - | Santos Laguna | 1:1 | ||||
4. Round | 16/08/2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
5. Round | 19/08/2021 | Santos Laguna | - | Atlas Guadalajara | 1:1 | ||||
6. Round | 22/08/2021 | Club León | - | Santos Laguna | 1:1 | ||||
7. Round | 30/08/2021 | Santos Laguna | - | FC Juárez | 2:0 | ||||
8. Round | 11/09/2021 | Club Tijuana | - | Santos Laguna | 2:1 | ||||
9. Round | 20/09/2021 | Santos Laguna | - | Puebla FC | 1:1 | ||||
10. Round | 27/09/2021 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
13. Round | 17/10/2021 | CF Pachuca | - | Santos Laguna | 1:1 |