| 2. Round | 15/05/2021 | Sporting Kansas City 2 | - | Colorado Springs Switchbacks | 0:4 | ||||
| 3. Round | 06/06/2021 | Colorado Springs Switchbacks | - | San Antonio FC | 1:1 | ||||
| 3. Round | 17/06/2021 | Colorado Springs Switchbacks | - | Tacoma Defiance | 4:2 | ||||
| 3. Round | 23/06/2021 | Austin Bold | - | Colorado Springs Switchbacks | 2:3 | ||||
| 3. Round | 26/06/2021 | Colorado Springs Switchbacks | - | New Mexico United | 3:1 | ||||
| 4. Round | 02/07/2021 | Colorado Springs Switchbacks | - | Orange County SC | 0:2 | ||||
| 5. Round | 11/08/2021 | Memphis 901 | - | Colorado Springs Switchbacks | 1:1 |  |
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| 5. Round | 15/08/2021 | Rio Grande Valley FC | - | Colorado Springs Switchbacks | 2:5 | ||||
| 6. Round | 05/09/2021 | New Mexico United | - | Colorado Springs Switchbacks | 3:2 | ||||
| 6. Round | 12/09/2021 | Colorado Springs Switchbacks | - | Rio Grande Valley FC | 1:1 | ||||
| 6. Round | 16/09/2021 | Colorado Springs Switchbacks | - | El Paso Locomotive | 0:0 | ||||
| 7. Round | 14/10/2021 | El Paso Locomotive | - | Colorado Springs Switchbacks | 4:2 | |
USA
Honduras