| 1. Round | 06/08/2005 | Southampton FC | - | Wolverhampton Wanderers | 0:0 | ||||
| 2. Round | 09/08/2005 | Luton Town | - | Southampton FC | 3:2 | ||||
| 3. Round | 13/08/2005 | Sheffield Wednesday | - | Southampton FC | 0:1 | ||||
| 9. Round | 18/09/2005 | Derby County | - | Southampton FC | 2:2 | ||||
| 14. Round | 18/10/2005 | Leeds United | - | Southampton FC | 2:1 | ||||
| 16. Round | 29/10/2005 | Southampton FC | - | Stoke City | 2:0 | ||||
| 18. Round | 05/11/2005 | Leicester City | - | Southampton FC | 0:0 | ||||
| 19. Round | 19/11/2005 | Southampton FC | - | Leeds United | 3:4 | ||||
| 20. Round | 22/11/2005 | Hull City | - | Southampton FC | 1:1 | ||||
| 21. Round | 26/11/2005 | Wolverhampton Wanderers | - | Southampton FC | 0:0 | ||||
| 22. Round | 03/12/2005 | Southampton FC | - | Burnley FC | 1:1 | ||||
| 23. Round | 11/12/2005 | Southampton FC | - | Luton Town | 1:0 |  |
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| 25. Round | 26/12/2005 | Watford FC | - | Southampton FC | 3:0 | ||||
| 26. Round | 28/12/2005 | Southampton FC | - | Sheffield United | 0:1 | ||||
| 27. Round | 31/12/2005 | Cardiff City | - | Southampton FC | 2:1 | ||||
| 30. Round | 21/01/2006 | Southampton FC | - | Ipswich Town | 0:2 |
England