| 1. Round | 21/08/2021 | SV Spakenburg | - | Jong FC Volendam | 2:2 | ||||
| 3. Round | 04/09/2021 | SV Spakenburg | - | VV Katwijk | 2:3 | ||||
| 5. Round | 18/09/2021 | SV Spakenburg | - | GVVV | 2:0 | ||||
| 6. Round | 25/09/2021 | Rijnsburgse Boys | - | SV Spakenburg | 3:1 | ||||
| 7. Round | 02/10/2021 | ASWH Ido-Ambacht | - | SV Spakenburg | 3:1 | ||||
| 8. Round | 09/10/2021 | SV Spakenburg | - | Excelsior Maassluis | 4:2 | ||||
| 9. Round | 16/10/2021 | HHC Hardenberg | - | SV Spakenburg | 3:3 | ||||
| 12. Round | 13/11/2021 | SV Spakenburg | - | VV Noordwijk | 2:0 | ||||
| 24. Round | 09/04/2022 | SV Spakenburg | - | Sparta Rotterdam (J) | 0:3 |
Netherlands