| 5. Round | 21/08/2021 | Club León [U16] | - | CF Monterrey [U16] | 0:1 | ||||
| 6. Round | 28/08/2021 | CF Monterrey [U16] | - | UANL Tigres [U16] | 1:1 | ||||
| 10. Round | 25/09/2021 | CF Monterrey [U16] | - | Mazatlán FC [U16] | 4:0 | ||||
| 12. Round | 09/10/2021 | CF Monterrey [U16] | - | Atlético San Luis [U16] | 3:1 | ||||
| 13. Round | 16/10/2021 | Santos Laguna [U16] | - | CF Monterrey [U16] | 1:1 | ||||
| 14. Round | 23/10/2021 | UANL Tigres [U16] | - | CF Monterrey [U16] | 0:0 |  |
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| 15. Round | 30/10/2021 | CF Monterrey [U16] | - | Deportivo Guadalajara [U16] | 1:7 | ||||
| 17. Round | 13/11/2021 | CF Monterrey [U16] | - | Club León [U16] | 0:3 | ||||
| 18. Round | 20/11/2021 | Club Necaxa [U16] | - | CF Monterrey [U16] | 1:1 |
Mexico