| 1. Round | 27/01/2023 | Libertad | - | Guaraní | 1:0 | ||||
| 2. Round | 03/02/2023 | Guaraní | - | Sportivo Ameliano | 2:2 | ||||
| 3. Round | 11/02/2023 | Cerro Porteño | - | Guaraní | 1:1 |  |
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| 4. Round | 17/02/2023 | Resistencia SC | - | Guaraní | 0:4 | ||||
| 5. Round | 25/02/2023 | Guaraní | - | Sportivo Luqueño | 3:1 | ||||
| 6. Round | 03/03/2023 | Club Nacional | - | Guaraní | 0:2 | ||||
| 7. Round | 14/03/2023 | Guaraní | - | Tacuary | 1:0 | |
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| 8. Round | 19/03/2023 | Sportivo Trinidense | - | Guaraní | 1:1 | ||||
| 9. Round | 24/03/2023 | Guaraní | - | Guaireña FC | 1:1 | |
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| 10. Round | 01/04/2023 | Club Olimpia | - | Guaraní | 0:1 | ||||
| 11. Round | 11/04/2023 | Guaraní | - | General Caballero DJLM | 3:1 | |
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| 13. Round | 17/04/2023 | Sportivo Ameliano | - | Guaraní | 1:1 | ||||
| 14. Round | 25/04/2023 | Guaraní | - | Cerro Porteño | 0:3 | |
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| 16. Round | 06/05/2023 | Sportivo Luqueño | - | Guaraní | 3:0 | |
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| 17. Round | 14/05/2023 | Guaraní | - | Club Nacional | 2:2 | ||||
| 18. Round | 18/05/2023 | Tacuary | - | Guaraní | 1:3 | |
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| 20. Round | 29/05/2023 | Guaireña FC | - | Guaraní | 2:2 | |
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| 21. Round | 03/06/2023 | Guaraní | - | Club Olimpia | 1:2 |
Argentina