| 1. Round | 09/07/2023 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 2. Round | 16/07/2023 | Guaraní | - | Libertad | 0:3 | ||||
| 5. Round | 06/08/2023 | Club Olimpia | - | Guaraní | 5:3 | ||||
| 6. Round | 13/08/2023 | Guaireña FC | - | Guaraní | 2:1 | ||||
| 7. Round | 19/08/2023 | Guaraní | - | Sportivo Ameliano | 0:3 |  |
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| 9. Round | 03/09/2023 | Guaraní | - | Resistencia SC | 3:2 | ||||
| 14. Round | 09/10/2023 | Guaraní | - | Tacuary | 2:0 | ||||
| 15. Round | 18/10/2023 | Club Nacional | - | Guaraní | 4:0 | |
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| 18. Round | 01/11/2023 | Sportivo Ameliano | - | Guaraní | 0:0 | ||||
| 19. Round | 05/11/2023 | Guaraní | - | General Caballero DJLM | 2:0 | |
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| 20. Round | 13/11/2023 | Resistencia SC | - | Guaraní | 0:1 | ||||
| 22. Round | 01/12/2023 | Cerro Porteño | - | Guaraní | 4:0 |
Argentina