| 2. Round | 24/07/2021 | Academica Clinceni | - | CFR Cluj | 1:2 | ||||
| 5. Round | 13/08/2021 | CFR Cluj | - | Farul Constanța | 1:0 | ||||
| 6. Round | 21/08/2021 | Argeș Pitești | - | CFR Cluj | 0:1 | ||||
| 7. Round | 29/08/2021 | CFR Cluj | - | FCSB | 4:1 |  |
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| 8. Round | 11/09/2021 | FC Botoşani | - | CFR Cluj | 1:0 | ||||
| 12. Round | 17/10/2021 | Rapid Bucureşti | - | CFR Cluj | 2:0 | ||||
| 16. Round | 20/11/2021 | FC Universitatea Craiova | - | CFR Cluj | 0:2 | |
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| 17. Round | 29/11/2021 | CFR Cluj | - | Academica Clinceni | 2:0 | |
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| 18. Round | 04/12/2021 | Chindia Târgoviște | - | CFR Cluj | 0:1 | ||||
| 19. Round | 12/12/2021 | CFR Cluj | - | CS Mioveni | 1:0 |
Iceland