| 4. Round | 15/08/2021 | FK Chayka | - | Chernomorets Novorossisk | 1:0 | ||||
| 5. Round | 21/08/2021 | Chernomorets Novorossisk | - | Anzhi Makhachkala | 2:0 | ||||
| 6. Round | 29/08/2021 | FK Druzhba | - | Chernomorets Novorossisk | 0:1 | ||||
| 7. Round | 04/09/2021 | Chernomorets Novorossisk | - | Alania-2 Vladikavkaz | 5:0 | ||||
| 8. Round | 08/09/2021 | Kuban-Holding Pavlovskaya | - | Chernomorets Novorossisk | 0:3 | ||||
| 9. Round | 12/09/2021 | Chernomorets Novorossisk | - | Forte Taganrog | 2:2 | ||||
| 10. Round | 18/09/2021 | FK Dinamo Makhachkala | - | Chernomorets Novorossisk | 3:0 | ||||
| 12. Round | 04/10/2021 | FK Tuapse | - | Chernomorets Novorossisk | 0:1 | ||||
| 13. Round | 10/10/2021 | Chernomorets Novorossisk | - | FK SKA Rostov | 0:1 | ||||
| 14. Round | 17/10/2021 | Dinamo Stavropol | - | Chernomorets Novorossisk | 1:1 | ||||
| 16. Round | 31/10/2021 | Chernomorets Novorossisk | - | FK Yessentuki | 5:0 | ||||
| 17. Round | 06/11/2021 | FK Biolog Novokubansk | - | Chernomorets Novorossisk | 2:2 | ||||
| 18. Round | 13/11/2021 | Chernomorets Novorossisk | - | FK Mashuk KMV | 3:2 |  |
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| 19. Round | 19/11/2021 | Spartak Nalchik | - | Chernomorets Novorossisk | 1:0 |
Russia