| 1. Round | 18/03/2018 | Sacramento Republic | - | San Antonio FC | 2:1 | ||||
| 1. Round | 25/03/2018 | San Antonio FC | - | Saint Louis FC | 2:1 | ||||
| 1. Round | 31/03/2018 | Los Angeles Galaxy II | - | San Antonio FC | 0:0 | ||||
| 2. Round | 08/04/2018 | San Antonio FC | - | Swope Park Rangers | 1:1 | ||||
| 2. Round | 15/04/2018 | San Antonio FC | - | Orange County SC | 0:3 |  |
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| 2. Round | 23/04/2018 | Fresno FC | - | San Antonio FC | 0:0 | ||||
| 2. Round | 28/04/2018 | Las Vegas Lights FC | - | San Antonio FC | 1:3 | ||||
| 3. Round | 06/05/2018 | San Antonio FC | - | Fresno FC | 2:1 | |
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| 3. Round | 13/05/2018 | Rio Grande Valley FC | - | San Antonio FC | 0:0 | |
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| 3. Round | 20/05/2018 | San Antonio FC | - | Tulsa Roughnecks | 1:1 | |
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| 3. Round | 27/05/2018 | Reno 1868 FC | - | San Antonio FC | 2:1 | ||||
| 4. Round | 03/06/2018 | San Antonio FC | - | Portland Timbers 2 | 2:1 | ||||
| 4. Round | 17/06/2018 | San Antonio FC | - | Sacramento Republic | 1:0 | ||||
| 4. Round | 24/06/2018 | San Antonio FC | - | Reno 1868 FC | 0:2 | ||||
| 5. Round | 22/07/2018 | San Antonio FC | - | Real Monarchs SLC | 4:2 | ||||
| 6. Round | 26/08/2018 | San Antonio FC | - | Swope Park Rangers | 1:2 |
USA