1. Round | 14/08/2021 | Heracles Almelo | - | PSV Eindhoven | 0:2 | ||||
2. Round | 21/08/2021 | PSV Eindhoven | - | SC Cambuur | 4:1 | ||||
3. Round | 28/08/2021 | PSV Eindhoven | - | FC Groningen | 5:2 | ||||
5. Round | 19/09/2021 | PSV Eindhoven | - | Feyenoord | 0:4 | ||||
6. Round | 22/09/2021 | Go Ahead Eagles | - | PSV Eindhoven | 1:2 | ||||
8. Round | 03/10/2021 | PSV Eindhoven | - | Sparta Rotterdam | 2:1 |