| 3. Round | 22/03/2025 | Detroit City FC | - | Birmingham Legion | 2:2 |  |
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| 4. Round | 29/03/2025 | Louisville City FC | - | Detroit City FC | 2:0 | ||||
| 5. Round | 05/04/2025 | Detroit City FC | - | Monterey Bay FC | 0:0 | ||||
| 6. Round | 13/04/2025 | Phoenix Rising | - | Detroit City FC | 2:3 | ||||
| 7. Round | 19/04/2025 | Detroit City FC | - | Rhode Island FC | 2:0 | ||||
| 8. Round | 04/05/2025 | Indy Eleven | - | Detroit City FC | 2:2 | |
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| 9. Round | 11/05/2025 | Hartford Athletic | - | Detroit City FC | 0:0 | |
England