| 6. Round | 19/09/2021 | New Mexico United | - | Real Monarchs SLC | 2:1 |  |
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| 6. Round | 26/09/2021 | San Antonio FC | - | New Mexico United | 0:1 | ||||
| 6. Round | 30/09/2021 | New Mexico United | - | Rio Grande Valley FC | 2:0 |  |
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| 7. Round | 07/10/2021 | New Mexico United | - | Hartford Athletic | 2:2 | |
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| 7. Round | 10/10/2021 | New Mexico United | - | Rio Grande Valley FC | 1:1 | ||||
| 7. Round | 17/10/2021 | San Diego Loyal | - | New Mexico United | 1:1 | ||||
| 7. Round | 21/10/2021 | New Mexico United | - | San Antonio FC | 4:2 | ||||
| 7. Round | 24/10/2021 | Rio Grande Valley FC | - | New Mexico United | 2:0 | ||||
| 7. Round | 31/10/2021 | New Mexico United | - | Real Monarchs SLC | 3:1 | |
USA