| 14. Round | 20/11/2021 | Stade Rennais | - | Montpellier HSC | 2:0 | ||||
| 18. Round | 11/12/2021 | Stade Brestois 29 | - | Montpellier HSC | 0:4 | ||||
| 23. Round | 05/02/2022 | AS Saint-Étienne | - | Montpellier HSC | 3:1 | ||||
| 26. Round | 25/02/2022 | Montpellier HSC | - | Stade Rennais | 2:4 | ||||
| 28. Round | 12/03/2022 | Montpellier HSC | - | OGC Nice | 0:0 | ||||
| 30. Round | 03/04/2022 | Montpellier HSC | - | Stade Brestois 29 | 1:2 | ||||
| 33. Round | 20/04/2022 | RC Lens | - | Montpellier HSC | 2:0 | ||||
| 35. Round | 01/05/2022 | Montpellier HSC | - | FC Metz | 2:2 | ||||
| 36. Round | 08/05/2022 | Clermont Foot 63 | - | Montpellier HSC | 2:1 | ||||
| 37. Round | 14/05/2022 | Montpellier HSC | - | Paris Saint-Germain | 0:4 | ||||
| 38. Round | 21/05/2022 | Angers SCO | - | Montpellier HSC | 2:0 |
France