| 1. Round | 08/01/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 | ||||
| 2. Round | 15/01/2022 | Club Tijuana [U18] | - | Club León [U18] | 1:2 | ||||
| 3. Round | 21/01/2022 | Puebla FC [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 4. Round | 05/02/2022 | Club Tijuana [U18] | - | Pumas UNAM [U18] | 2:0 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 | ||||
| 7. Round | 25/02/2022 | Club Tijuana [U18] | - | Atlas Guadalajara [U18] | 3:3 | ||||
| 8. Round | 01/03/2022 | Deportivo Toluca [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 10. Round | 12/03/2022 | Santos Laguna [U18] | - | Club Tijuana [U18] | 4:0 | ||||
| 11. Round | 18/03/2022 | Club Tijuana [U18] | - | FC Juárez [U18] | 3:2 |  |
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| 13. Round | 11/04/2022 | CF Pachuca [U18] | - | Club Tijuana [U18] | 1:2 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U18] | - | CF América [U18] | 2:0 | ||||
| 16. Round | 24/04/2022 | Club Tijuana [U18] | - | Gallos Blancos [U18] | 4:1 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U18] | - | Club Tijuana [U18] | 1:1 |
USA
Mexico