| 2. Round | 07/08/2005 | Olympique Lyonnais | - | RC Strasbourg | 1:0 | ||||
| 5. Round | 27/08/2005 | RC Strasbourg | - | Girondins Bordeaux | 0:0 | ||||
| 6. Round | 10/09/2005 | Paris Saint-Germain | - | RC Strasbourg | 1:0 | ||||
| 7. Round | 18/09/2005 | RC Strasbourg | - | RC Lens | 1:1 | ||||
| 8. Round | 21/09/2005 | AC Ajaccio | - | RC Strasbourg | 0:0 | ||||
| 9. Round | 24/09/2005 | RC Strasbourg | - | Toulouse FC | 2:4 | ||||
| 11. Round | 15/10/2005 | RC Strasbourg | - | Stade Rennais | 0:1 | ||||
| 13. Round | 29/10/2005 | RC Strasbourg | - | AS Saint-Étienne | 0:1 | ||||
| 14. Round | 06/11/2005 | Lille OSC | - | RC Strasbourg | 2:0 | ||||
| 15. Round | 19/11/2005 | RC Strasbourg | - | OGC Nice | 0:0 | ||||
| 16. Round | 27/11/2005 | FC Nantes | - | RC Strasbourg | 4:3 | ||||
| 17. Round | 03/12/2005 | RC Strasbourg | - | FC Sochaux | 0:0 | ||||
| 37. Round | 06/05/2006 | Olympique Marseille | - | RC Strasbourg | 2:2 | ||||
| 38. Round | 13/05/2006 | AJ Auxerre | - | RC Strasbourg | 4:0 |
France